A contract is signed between the Commission of the European Communities and the Council of Europe putting the European Pharmacopoeia Secretariat in charge of a biological standardisation programme; Directives 91/507/EEC and 92/18/EEC revise Directives 75/318/EEC and 81/852/EEC respectively allowing all medicines, notably biologicals, to be covered by EU law; the EDQM participates in the International Conference on Harmonisation (ICH).