CombiStats Online - Training
Date: 18 to 22 November 2024
Location: online
Language: English
CombiStats is a software application developed by the EDQM to perform calculations as described in European Pharmacopoeia General Chapter 5.3. Statistical analysis of results of biological assays and tests.
CombiStats Online was released on 4 July 2024. This brand new version offers a flexible licence management system, a dedicated workspace, a modern user-friendly interface and a large set of statistical models and options.
This training course will demonstrate the main functionalities and new features of this latest release across 4 modules:
- Module 1: Introduction to the online application
- Module 2: Assays based on quantal response
- Module 3: Assays based on quantitative response
- Module 4: Single-dose assays, combination of assay results
Each module will feature a live Q&A.
You can choose to sign up for all the modules or just the one(s) you are most interested in.
Module 1: Introduction to the online application
18 November 2024 – 13:30 – 16:00 (CET, France) Live webinar
This module will begin with an overview of CombiStats Online. You will learn about the new ordering process, how to activate your workspace, how to create and manage accounts. The creation and management of assays and templates (.epax and .epmx files) will then be explored, which will cover the protection, sharing and import/export of files. This will be followed by an item on data entry, including the Show design option and the audit trail (available in the analysis report). Tips for batch creating .epax files will also be shared, and the demonstrations will conclude with an overview of the documentation (FAQs, user guide, privacy and security notices).
The presentations will be followed by a live Q&A session.
Module 3: Assays based on quantitative response
20 November 2024 – 13:30 – 16:30 (CET, France) Live webinar
This module will give an overview of different regression models used to analyse quantitative data (slope-ratio, parallel lines including subset analysis, 4/5-parameter logistic and 3-parameter exponential models). The various analysis options available for each model will be explained, and the tables of results and graphical representations (e.g. potency estimates, ANOVA, plot of residuals) will also be covered.
The presentations will be followed by a live Q&A session.
Module 2: Assays based on quantal response
19 November 2024 – 13:30 – 15:30 (CET, France) Live webinar
This module will begin with a presentation of the 4-parameter logistic regression model used to analyse quantal (e.g. pass/fail) data. This will be followed by examples of data entry in the data tables or using the Show design option (aggregated data vs individual data) and an overview of the various analysis options and tables of results and graphical representations (e.g. ED50, potency estimates, ANOVA, plot of residuals).
The presentations will be followed by a live Q&A session.
Module 4: Single-dose assays, combination of assay results
22 November 2024 – 13:30 – 15:30 (CET, France) Live webinar
This module will begin with a presentation of the limit test (the Wilcoxon-Mann-Whitney test) performed by CombiStats on single-dose assays. The examples studied will address in particular how to correctly interpret the p-value of the test. In the second part of this module the fundamentals of the 3 combination approaches will be presented, followed by examples of combining assay files (.epax). Finally, you will learn about the available options and calculated results in combined files (.epcx).
The presentations will be followed by a live Q&A session.
These webinars will be of interest to professionals from the pharmaceutical industry, regulatory agencies and academic institutions who are responsible for analysing and interpreting assay data using the new CombiStats Online application.
Participation is free of charge.
The registration link is given under each module.
Participants can register to attend all the modules OR a selection of individual modules.
After registration, you will receive an invitation telling you how to access the webinar and how to test the system beforehand. On the day of the webinar, click on the link in the registration confirmation e-mail.
You can also check your system’s compatibility automatically.
Before registering, please read the Terms of Supply for EDQM Events.
All the training modules (webinars) are free of charge.
Places are limited, so sign up today!
Each registered participant will receive a copy of the presentation slides and the link to the webinar recording which they can refer back to if needed in the future.
